Monday, November 5, 2012

Wubs and Wobbles

While caffeine can cause a neurotransmitter cascade via its dopamine agonism pathway1, L-carnitine supplementation increases FFA (fatty acid concentration) uptake by mitochondria2 - such is true of neural mitochondria and increases their ability to form vesicles.

While we all know that testosterone can stimulate dopaminergism, less understood are presynaptic dopamine neurons' role in potentiating the cholinergic pathways which stimulate vasopressin secretion3.

Although vasopressin commonly causes aggression, it improves memory3 and is co-released with serotonin3, a chemical that induces emotional bonding. Such bonding entrains its object as an oxytocin stimulus and is a factor in receptivity to it4. Vasopressin stimuli are subject to a deeper degree of preferentiality6, and the excessive imprinting of them is subject to optimal nutrient utilization by the brain - you don't want the limbic system sucking up too much of circulating nutrient concentrations.

1http://www.apa.org/monitor/mar05/dopamine.aspx
2http://www.ncbi.nlm.nih.gov/pubmed/3308409
3http://www.sciencemag.org/content/211/4482/601.short
4http://www.neurotransmitter.net/avp.html
5http://endo.endojournals.org/content/128/6/3269.short
6http://research.yerkes.emory.edu/Young/Getz/1993%20Winslow%20N.pdf

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